Marvin Tanenbaum Group

Single molecule analysis of gene expression dynamics

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Our Focus

The Tanenbaum group uses cutting-edge live-cell single-molecule microscopy and new types of genetic engineering to uncover the molecular mechanisms of gene expression control in individual cells. Our work focuses both on regulation of human genes in health and disease and on gene regulation of RNA viruses. Using our single-molecule approaches, we aim to uncover how the dynamics and heterogeneity in gene expression affects cell fate. In addition, we are developing new imaging technologies to visualize gene expression dynamics with ever increasing resolution to achieve a deep molecular understanding of these processes.  

About Marvin Tanenbaum

Name

Marvin Tanenbaum

Position
Oncode Investigator at Hubrecht Institute and Professor in the department of Bionanoscience at the TU Delft
My Research

Marvin Tanenbaum received his PhD (Cum Laude) in 2010 from Utrecht University for his work on cell division in the group of Prof. René Medema. During his PhD work, Marvin used live-cell microscopy to study the molecular mechanism of chromosome segregation during cell division. After obtaining his PhD, he received KWF and EMBO fellowships to perform his postdoctoral research in the group of Prof. Ron Vale at UCSF in the United States. As a postdoc, Marvin developed a keen interest in studying the control mechanisms and dynamics of gene expression in single cells, focusing on gene expression control during the cell cycle. He pioneered several new techniques using protein engineering that enabled direct observation of single protein molecules in action, and developed methods to observe gene expression in single living cells by fluorescence microscopy. He also developed a technique to modulate the activity of individual genes in single cells. In 2015, he became a group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single-molecule level, both for humans and in viruses, and aims to understand how control of gene expression affects important cellular decisions.

Awards
  • Elected EMBO member in 2022

  • Recipient of an ERC Consolidator grant in 2022

  • Prix Galien Excellence COVID-19 Award in 2021

  • EMBO young investigator (YIP) in 2019

  • Recipient of a VIDI grant in 2018

  • Howard Hughes Medical Institute (HHMI) International Research Scholar in 2017

  • Recipient of an ERC Starting grant in 2015

  • Recipient of EMBO Long-term fellowship in 2011

  • Recipient of a Dutch Cancer Society postdoctoral fellowship in 2011

  • NVMO Oncology Thesis Award in 2011

  • Utrecht University Thesis Prize in 2011

Key Publications
  1. Boersma S, Rabouw HH, Bruurs LJM, [...] van Kuppeveld F, Tanenbaum ME (2020). Translation and Replication Dynamics of Single RNA VirusesCell, 183, 1–16.

  2. Hoek TA, Khuperkar D, Lindeboom RGH, [...] Tanenbaum ME (2019). Single-molecule imaging uncovers rules governing nonsense-mediated mRNA decayMolecular Cell, 75(2), 324-339.

  3. Boersma S, Khuperkar D, Verhagen BMP, [...] Tanenbaum ME (2019). Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decodingCell, 178(2), 458-472.

  4. Yan, X., Hoek, T. A., Vale, R. D., & Tanenbaum, M. E. (2016). Dynamics of translation of single mRNA molecules in vivo. Cell165(4), 976-989.

  5. Ruijtenberg S, Sonneveld S, Cui TJ, [...] Tanenbaum ME (2020). mRNA structural dynamics shape Argonaute-target interactionsNat Struct Mol Biol, 28(6), 533.

  6. Krijger PHL, Hoek TA, [...] de Laat W, Tanenbaum ME (2021). A public-private partnership model for COVID-19 diagnostics. Nat Biotechnol. 39(10), 1182-1184.

Members

Marvin Tanenbaum
Groupleader
Bernhard Kramer    
PostDoc
Bram Verhagen    
PhD Student
Dhanushika Ratnayake    
Post Doc
Huib Rabouw    
Postdoc fellow
Jakob Püschel    
Phd Student
Janin Schokolowski    
Phd student
Leonie Apperloo    
Technician
Marloes van Drimmelen    
PhD student
Matthijs Baars    
Data scientist
Maximilian Madern    
Phd Student
Micha Müller    
PhD Student
Sora Yang    
Post Doc
Thomas Sabate    
Postdoc