Michiel Vermeulen Group

Proteomics & Chromatin biology

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Our Focus

The main focus of our lab is to decipher (epi)genetic regulation of gene expression and cell fate in (differentiated) stem cells using integrative omics approaches. Furthermore, we use the same technology to study deregulation of gene expression in cancer. Our lab also develops new proteomics and genomics technology for cancer research, which we make available to the Oncode community.  

  

Current main research questions include:  

  

  • What are the molecular mechanisms of context-dependent oncogenes and tumour suppressors in CRC  
  • How do chromatin associated proteins synergize with transcription factors to regulate gene expression and cell fate?  

About Michiel Vermeulen

My Research

Michiel Vermeulen performed his doctoral work in the laboratory of Henk Stunnenberg at the University of Nijmegen in the Netherlands. In 2005 he joined the lab of Matthias Mann in Munich, Germany as a post-doctoral fellow. In 2009 he was appointed as assistant professor and in 2013 as associate professor at the University Medical Center Utrecht in The Netherlands. In February 2014 he was appointed as full professor at the Radboud University in Nijmegen, The Netherlands. Since February 2023 he also holds a part-time position as senior group leader at the Dutch Cancer Institute. The group currently consists of 8 PhD students, 5 post-docs and 3 technicians. Awarded grants include NWO-VIDI (2009), an ERC Starting Grant (2012), an ERC Consolidator Grant (2017) and an NWO-VICI (2021). He was elected as member of Academia Europeae in 2019 and an a member of EMBO in 2022.

Awards
  • 2022: Elected Member, European Molecular Biology Organization (EMBO)
  • 2021: NWO Vici Grant
  • 2019: Elected Member, Academia Europaea
  • 2018: ERC Consolidator Grant
  • 2012: ERC Starting Grant
  • 2009: NWO Vidi Grant
  • 2008: Max Planck Institute for Biochemistry Junior Research Award
  • 2000: Van Nieuwenhoven Award for Best Undergraduate Student in Biology, University of Nijmegen
Key Publications
  • 2024 | Deciphering lineage specification during early embryogenesis in mouse gastruloids using multi-layered proteomics | Suzan Stelloo et al. | Cell Stem Cell | View publication
  • 2023 | Quantification of absolute transcription factor binding affinities in the native chromatin context using BANC-seq | Hannah K. Neikes et al. | Nature Biotechnology | View publication
  • 2021 | Off-the-shelf proximity biotinylation for interaction proteomics | Irene Santos-Barriopedro et al. | Nature Communications | View publication
  • 2021 | Reading ADP-ribosylation using chemical biology and interaction proteomics | Katarzyna W. Kliza et al. | Molecular Cell | View publication
  • 2018 | Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry | Matthew M. Makowski et al. | Nature Communications | View publication
  • 2017 | An interaction landscape of ubiquitin signaling | Xiaofei Zhang et al. | Molecular Cell | View publication
  • 2017 | N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis | Raghu R. Edupuganti et al. | Nature Structural & Molecular Biology | View publication
  • 2013 | Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives | Cornelia G. Spruijt et al. | Cell | View publication
  • 2010 | Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers | Michiel Vermeulen et al. | Cell | View publication
  • 2007 | Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4 | Michiel Vermeulen et al. | Cell | View publication

Members

Michiel Vermeulen
Group leader
Aniek Martens      
Phd student
Aniek Verstappen    
Phd student
Balaji Srinivasan    
PostDoc
Inge De Krijger     
Postdoc
Lieke Lamers    
Technician
Margit Janssen    
PhD student
Maria-Teresa Alejo Vinogradova     
Phd student
Marijke Baltissen    
Technician
Martijn Hendriksen    
Research analyst
Suzan Stelloo    
Post Doc
 
Suzanne Weijers     
Phd student
Yunna Erika Strøm    
PhD student