Jan Paul Medema is Scientific and chair of the Research Management Committee of Oncode Institute. He is also group leader at Amsterdam University Medical Centers and Professor Experimental Oncology and Radiobiology at the University of Amsterdam. His group studies the biology and therapy of colorectal cancer from a heterogeneity point of view considering both the intra tumor heterogeneity that is defined by a CSC hierarchy as well as by clonal evolution and inter-tumor heterogeneity, which is defined by distinct subtypes as well as mutation profiles.